Saturday, May 23, 2015

Joint Rejuvenation


What is Cyplexinol?

In the early 1960’s, an orthopedic surgeon name Dr. Marshall Urist asked the question - what is it in bones that allows them to regenerate? This question fueled his research as the head of bone research at UCLA. Dr. Urist discovered a new protein which, when mixed with a specific stem cell (namely, mesenchymal stem cell or MSC) this protein activated those cells and turned them into bone and cartilage building cells (osteoblasts and chondrocytes). Dr. Urist noted the stem cells changed or morphed into these bone and cartilage building cells and so he named this new protein Bone Morphogenetic Protein (BMPs). In 1965 he published his findings in the prestigious journal of Science entitled, The Autoinduction of Bone, as he coined the term osteoinductivity – the ability of a protein to turn on stem cells to grow bone and cartilage tissue.

The impact of Dr. Urist’s contribution to medicine and healthcare wasn’t truly realized until the early 1990’s when the first commercial BMP-complex was used by orthopedic surgeons for bone healing and spinal fusions. This natural complex contained the BMPs found in bone along with key growth factor. The BMPs activate, stimulate and transform the MSCs into osteoblasts and chondrocytes while the growth factor assist in the maturation of the new cells so that bone and cartilage tissue can grow.

Pharmaceuticals and biotech companies have worked on developing synthetic versions of some of the BMPs. Even with today’s technology it is impossible to synthetically create the natural protein complex with the BMPs and growth factors bound to it possessing the same pharmacokinetics and clinical results.

Cyplexinol is a partially hydrolyzed collage/BMP- complex, which contains:

  • BMPs (Bone Morphogenetic Proteins)
  • TGF-Beta (Transforming Growth Factor Beta)
  • PDGF (Platelet Derived Growth Factor)
  • IGF (Insulin-like Growth Factor)
  • bFGF (Basic Fibroblastic Growth Factor)
  • VEGF (Vascular Endothelial Growth Factor)

Cyplexinol (Nature’s BMP – complex):

  • Naturally activates bone & cartilage growth*
  • Is functionally involved in bone & cartilage formation*
  • Help maintain natural bone & joint homeostasis*
  • Has a natural immunoprotective effects against inflammation*


What is Glucosamine?

Glucosamine is a compound found naturally in the body, made from glucose and the amino acid glutamine. Glucosamine is needed to produce glycosaminoglycan, a molecule used in the formation and repair of cartilage and other body tissues. Production of glucosamine slows with age.

There are no major food sources of glucosamine, so you must get it from supplements. Most supplements are made from chitin, the hard outer shells of shrimp, lobsters, and crabs. Other forms of glucosamine are available for people who are allergic to shellfish.

Glucosamine is available in oral supplements as glucosamine sulfate, glucosamine hydrochloride, and n-acetyl glucosamine. These products may come in tablet, capsule, and powder forms. It is often combined with chondroitin and sometimes manganese as well. Manganese is a trace element necessary for normal bone health. The total amount of manganese from foods and supplements should not exceed 11 mg per day, but several combination supplements for arthritis (containing glucosamine, chondroitin, and manganese) have more than that. Read labels carefully, and consider choosing a supplement without manganese..

Glucosamine is also available as an injectable form that we can insert directly into a joint.

Glucosamine supplements are widely used for osteoarthritis, particularly knee osteoarthritis. In osteoarthritis, cartilage -- the rubbery material that cushions joints -- becomes stiff and loses its elasticity. This makes the joint prone to damage and may lead to pain, swelling, loss of movement, and further deterioration.

Please call our office to discuss all of our arthritis and joint rejuvenation therapies such as Platelet Rich Plasma. Call 727.518.9808 to schedule your appointment today!


Orthomolecular Nutrition
and Wellness Center
9225 Ulmerton Rd., Suite 312
Largo, FL. 33771

Ayurvedic Proverb
"If diet is wrong, medicine is of no use. If diet is correct, medicine is of no need."
Ronald Klatz, D.O.

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Mike Adams

“Today, more than 95% of all chronic disease is caused by food choice, toxic food ingredients, nutritional deficiencies and lack of physical exercise.”

Michael Tierra

“Diet is the essential key to all successful healing. Without a proper balanced diet, the effectiveness of herbal treatment is very limited."

The Scientist Magazine

“Unfortunately, everything the experts tell us about diet is aimed at the whole population, and we are not all the same.”


“Our food should be our medicine and our medicine should be our food.”


“The first wealth is health.”


“Life is not living, but living in health.”

Rockefeller Institute of Medicine research

“If the doctors of today do not become the nutritionists of tomorrow, then the nutritionists of today will become the doctors of tomorrow.”

Orthomolecular Nutrition & Wellness Center, LLC, Health & Wellness, Largo, FL
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