NeuroLab™ from Sanesco provides our patients with 3 primary profiles that measure 6 primary urinary neurotransmitters: Serotonin, GABA, Glutamate, Dopamine, Norepinephrine, and Epinephrine. Salivary adrenal hormones are also measured: 4 timed Cortisols and 2 DHEA. This profile assesses the six neurotransmitters that affect the hypothalamic-pituitary axis (HP) as well as the adrenal hormones cortisol and DHEA. Since the HPA axis initiates an adrenal response, this profile allows the practitioner to assess that response and make therapeutic decisions based on the information. Neurotransmitters are measured from a single urine sample, while cortisol (X4) and DHEA (X2) are measured from four saliva samples, the first taken between 7:00 and 8:00 am and then one every five hours thereafter for the remaining three samples. Orthomolecular Nutrition & Wellness provides a correlation analysis that includes unique clinical decision support and risk management personalized with respect to your patients. Customized functional input is included in each report, as each patient has a unique biochemical make up and variety of lifestyle factors and symptoms. The clinical team is correlating patient lab values to symptoms and severity, medications and dosages, lifestyle factors, medical diagnoses, supplements, and demographics to best analyze these interrelated variables and what this means for you and your patient.
When a patient presents one or more symptoms to our practitioner, they are given the appropriate Sanesco test collection kit(s) to establish baseline levels. Each non-invasive urine and/or saliva test provides a convenient, at-home collection method that encourages patient compliance. Urine testing follows an CLIA-approved technology developed by Sanesco’s scientific board . The patient mails the collected sample(s) to Sanesco in a pre-addressed, postage-paid box. Together with the patient’s symptoms, it is logged by Sanesco and forwarded to NeuroLab™ for processing. Test results are sent to Sanesco, whose expert team of multi-disciplinary researchers and clinicians develops a recommended treatment protocol that takes into consideration the patient’s symptoms, the test results and the over 100 self-reported lifestyle, medication, supplementation, medical history factors. A copy of the test results is then forwarded to the practitioner together with Sanesco’s individualized interpretation and educational comments. Whenever requested, Sanesco’s expert team is also available to further interpret test results and assist the practitioner in selecting a viable therapeutic approach. A key advantage of Sanesco’s functional assessment protocol is testing frequency. After an initial baseline is established, it is very important to regularly retest a patient’s neuronal and hormonal responses to measure changes that occur over time. Once therapy is initiated,the patient’s levels begin to shift; retesting allows the restoration of a patient’s health, a period that may last from three to nine months, depending on the individual and the severity of their symptoms. When a patient’s symptoms are relieved and long-term health has been restored, annual or semi-annual testing is conducted to maintain the patient’s state of health and prevent the return of symptoms.
Baseline Laboratory Assessment
Sanesco’s CSM™ process begins with assessment of a patient’s neurotransmitter and adrenal hormone levels with a non invasive lab test. This first step is necessary to begin to fully understand our patient’s neuro-hormonal status. An initial test established a baseline, and helps reveal underlying imbalances that may contribute to the manifestation of symptoms. Unlike traditional test and treat diagnostic models. Our laboratory assessment includes non-invasive serial testing that allows you to monitor changes in neuronal and hormonal responses over time, letting us make adjustments to a patient’s therapeutic protocol to achieve an optimal neuroendocrine balance and effective clinical outcomes.
Retesting for Neuroendocrine Optimization
One of the cornerstones of the CSM™ clinical model is retesting. Monitoring neurotransmitter and hormone levels throughout the rebalancing process is the most effective way of guiding individual therapy. The patient’s current response can be measured against previous results and symptoms, allowing for imbalances to be more adequately addressed. Targeted Nutritional Therapy will be adjusted as results are viewed and compared. With each retest, the patient is moving closer to achieving HPA axis and symptom balance.Example showing the previous and current values are below.
What is a neurotransmitter?
The brain makes chemical messengers calledneurotransmitters. Neurotransmitters are produced and stored in the brain and are released into action when the brain cells are electronically activated. They areresponsible for every thought, mood, pain and pleasure sensation we feel. They controlour energy level, our appetite and the foods we crave. Neurotransmitters even regulatehow well we sleep as well as our sex drive. Psychological stress and physiological changes can cause neurotransmitter deficiencies orimbalances; likewise, the neurotransmitter deficiency or imbalance can causepsychological changes. Neurotransmitters can be easily measured by specialized noninvasivelaboratory testing. Thinking of it this way: it is common to measure thyroid levels before prescribingmedication and to test a diabetic’s blood sugar before adjusting the dose of insulin.Therefore, before treating an individual with neurotransmitter imbalances, it is importantto identify their specific levels in order to recommend the best therapeutic support. Neurotransmitters and hormones commonly measured are serotonin, dopamine, GABA,nor epinephrine, epinephrine, glutamate, cortisol, DHEA and thyroid. A deficiency ofany particular neurotransmitter not only affects neuronal function but also endocrinefunction anywhere in the body. Our endocrine system is considered primary and critical to all metabolic function.Glands such as the thyroid, the adrenals, the ovaries and the testes all take direction fromthe brain. There are many conditions that negatively impact hormone levels, and whenone hormone is imbalanced, there is a tendency for many other hormones to follow suit. Correction of imbalanced hormones is important but not always sufficient. Correction ofimbalanced neurotransmitters, on the other hand, is imperative if clinical progress is to bemade. Determining which neurotransmitters are low and which are high should precedeclinical intervention. For instance, combining poor diet with a stressful life-style is a recipe forneurotransmitter imbalances. The types of food we crave (starches, chocolate or sweets)and the time of day we crave them (late afternoon or evening) may characterize specific neurotransmitter deficiencies. In fact, serotonin depletion is one of the most commonneurotransmitter imbalances in our culture.
Common symptoms/conditions ofserotonin/dopamine imbalances include:
- Anxiety and panic attacks
- Strong craving for sweets
- Difficulty concentrating
- Headaches (including migraines)
- Low motivation
- Chronic pain
- Irritability and anger disorders
- Seasonal affective disorders
- Decreased sex drive
What causes neurotransmitter deficiencies?
Weight Loss / Dieting
Dieting is the most common cause of self-induced neurotransmitter deficiencies. Protein deficientdiets may not supply adequate tryptophan, which is necessary for serotoninproduction. Carbohydrate is necessary to deliver tryptophan to the brain for serotoninproduction. High protein/low carbohydrate diets are a two-fold problem – there is notenough insulin and too much amino acid competition, which restricts the basic buildingblocks needed to produce enough neurotransmitters. Studies from major universities, including Harvard, MIT and Oxford, have documentedthat women on diets significantly deplete their serotonin within three weeks of dieting! This induced serotonin deficiency eventually leads to increased cravings, moodiness andpoor motivation, which all contribute to rebound weight gain – the common yetunfortunate consequence of dieting. Diets may also be deficient in B-vitamins and othernecessary nutrients. Folic acid, B6, and magnesium are all required in the process ofserotonin production. Therefore, it is so important to see a health care professional foryour weight loss program where you have the opportunity for neurotransmitter supportthat can help ensure successful weight loss with a healthy program specifically designedfor you.
Long term use of diet pills, stimulants, pain pills, narcotics and recreational drugs candeplete neurotransmitter stores. Diet pills (like phen-fen , phenteramine) use up largeamounts of dopamine and serotonin, which can result in “rebound” appetite controlproblems, low energy, unstable moods and a sluggish metabolism.
Prolonged Emotional or Physical Stress
The human body is designed to handle sudden, acute or short bouts of stress. Prolongedchronic stress takes its toll on the “fight or flight” stress hormones and neurotransmitters.Eventually, these become depleted and coping becomes more difficult.
Sixty percent of all adults over the age of 40 have some degree of neurotransmitterdeficiencies. Aging brain cells make smalleramounts of neurotransmitters. Also, as weget older, the body does not respond as well to them.
Stressors of all sorts can become chronic and cause adrenal fatigue. Manyneurotransmitters are responsible for proper sleep, especially serotonin and are productduring REM sleep around 2 to 3 am when serotonin converts to melatonin, the sleephormone. When serotonin levels are low melatonin level will also be low. Disruptedsleep occurs and fewer neurotransmitters are produced causing a sleepless night.
Heavy Metal Toxicity
Mercury, lead, aluminum, cadmium and arsenic are major neurotoxins. Chemicalpesticides, fertilizers, certain cleaning agents, industrial solvents and recreational drugscause damage to the brain cells and decrease neurotransmitter production.
Any condition ending in “it is,’ such as sinusitis, gastritis or arthritis is an inflammatorycondition. Inflammation interferes with the conversion of tryptophan to 5-HTP which isused in the body’s production of serotonin.
If hormones are deficient or are off balance, neurotransmitters do not function well.Premenstrual Syndrome (PMS) is a classic example of how low serotonin levels can shifteach month. Mood, appetite and sleep can be severely disrupted one or two weeks beforethe menstrual cycle. Another neurotransmitter imbalance occurs during menopause whendramatic changes in mood, energy, sleep, weight and sexual desire occur.
Some people are born with a limited ability to make adequate amounts ofneurotransmitters. They exhibit deficiency symptoms as children or young adults andoften have relatives who suffer from significant mental illnesses. As they age, affectedindividuals experience even more profound symptoms and debilitation. To learn more about the lab we use for testing go to Sanesco’s website at: http://www.sanescohealth.com/neurolab/ Our practitioners will go over the extensive test results that we receive from the lab to provide a protocol to help balance and optimize your neurotransmitters.
What is CHELATION?
Chelation refers to the use of a substance that helps remove heavy metals or toxic substances from the body. Substances used in Chelation IV Therapy are medications called EDTA, DMPS, DMSA, or Vitamin C. The word chelate means “claw”. The substance claw or grabs onto the offending toxin and pulls it out of the body.
Orthomolecular Nutrition & Wellness uses chelation therapy as an effective way of removing toxins and harmful body wastes, as well as helping to prevent or treat atherosclerosis, heart attacks, strokes, and circulation problems.
The most popular form of chelation therapy is a drug called EDTA (ethylene diamine tetraacetic acid). EDTA is approved by the Food and Drug Administration (FDA) for treatment of lead and heavy metal poisoning but not for other forms of toxicity or circulatory problems. EDTA works by attaching itself to specific minerals, which are carried out of the body via urinary excretion.
The most common and toxic heavy metals that can poison our systems and lead to fatigue and illness are iron, lead, cadmium, and mercury. Iron is by far the most common of the heavy metals that predisposes individuals to heart disease. It promotes free radical activity and thereby leads to accelerated arterial damage. Lead and cadmium are common industrial pollutants that also foster free radical activity and poison critical enzymes which repair tissue. Mercury is found in some kinds of seafood and in dental fillings. Its toxicity can depress the immune system and cause an array of symptoms. Getting the iron, lead, cadmium, and mercury out can be accomplished with chelation therapy, which both prevents and can reverse heart disease, atherosclerosis, and the other problems mentioned above.
How does chelation therapy work?
For most of these metals, an intravenous solution of vitamins, minerals, and the chelator EDTA is prepared. EDTA is a substance known for its ability to pull heavy metals out of the body. This is infused into the bloodstream through a vein.
EDTA leaves the body in the same form by which it entered, but on its way out, it chelates metals and minerals from the body. Patients usually undergo between 10 and 20 chelation treatments over a period of weeks or months.
Beyond its effects on heavy metals, chelation with EDTA also helps to remove inappropriate accumulations of calcium from tissue. Calcium gravitates to atherosclerotic plaque in blood vessels, leading to arterial narrowing and blockage. Chelation gently and gradually mobilizes calcium from plaque, restoring elasticity and flow to blood vessels.
Orthomolecular has seen great improvement in high blood pressure, angina, leg cramps and diabetic leg ulcers as well as improvement in mental alertness and memory due to improved blood flow to all areas of the body from chelation iv therapy. Call Orthomolecular Nutrition & Wellness at 727-518-9808 to schedule your chelation iv therapy today.
Lyme disease is transmitted by the bite of a tick, and the disease is prevalent across the United States and throughout the world. Lyme disease is a clinical diagnosis. The disease is caused by a spiral-shaped bacteria (spirochete) called Borrelia burgdorferi. The Lyme spirochete can cause infection of multiple organs and produce a wide range of symptoms.
It has become the number one vector-borne disease in the United States. The CDC states that while over 20,000 cases are reported annually, the actual number is likely 10 times greater. Most doctors on the frontlines of Lyme clinical care believe the actual number is more like 25 times the CDC's reported case number. It is rare to meet a person who doesn't know someone who has had Lyme disease or is currently suffering from the effects of this disease.
It is called the new great imitator because of its ability to look like so many other diseases and conditions. Often misdiagnosed when the classic “bull's eye rash” is absent or when some of the unreliable blood tests are negative, Lyme is taking its toll in terms of human misery in the United States and many other countries. When Lyme is combined with other tick-borne infections, it becomes especially problematic.
Erythema migrans is the tell tale rash which occurs in about 70% to 80% of cases and starts as a small red spot that expands over a period of days or weeks, forming a circular, triangular, or oval-shaped rash. Sometimes the rash resembles a bull's-eye because it appears as a red ring surrounding a central clear area. The rash, which can range in size from that of a dime to the entire width of a person's back, appears between three days and a few weeks of a tick bite, usually occurring at the site of a bite. As infection spreads, several rashes can appear at different sites on the body.
Erythema migrans is often accompanied by symptoms such as fever, headache, stiff neck, body aches, and fatigue. These flu-like symptoms may resemble those of common viral infections.
After several weeks of being infected with Lyme disease, approximately 60% of those people not treated with antibiotics develop recurrent attacks of painful and swollen joints that last a few days to a few months. The arthritis can shift from one joint to another; the knee is most commonly affected and usually one or a few joints are affected at any given time. About 10% to 20% of untreated patients will go on to develop lasting arthritis. The knuckle joints of the hands are only very rarely affected.
Lyme disease can also affect the nervous system, causing symptoms such as stiff neck and severe headache (meningitis), temporary paralysis of facial muscles (Bell's palsy), numbness, pain or weakness in the limbs, or poor coordination. More subtle changes such as memory loss, difficulty with concentration, and a change in mood or sleeping habits have also been associated with Lyme disease. People with these latter symptoms alone usually don't have Lyme disease as their cause.
Nervous system abnormalities usually develop several weeks, months, or even years following an untreated infection. These symptoms often last for weeks or months and may recur.
Fewer than one out of 10 Lyme disease patients develops heart problems, such as an irregular, slow heartbeat, which can be signaled by dizziness or shortness of breath. These symptoms rarely last more than a few days or weeks. Such heart abnormalities generally appear several weeks after infection, and usually begin to resolve even before treatment.
Less commonly, Lyme disease can result in eye inflammation and severe fatigue, although none of these problems is likely to appear without other Lyme disease symptoms being present.
. Deer ticks require a damp, humid environment to survive and are most often found in wooded areas and wooded edges, especially in leaf litter and low ground cover. They are usually picked up on the lower leg and tend to crawl up the body looking for a place to attach and feed.
Some ticks are very small and difficult to spot, especially the nymph tick. Wearing light colored clothing whenever working or playing in tick endemic areas makes spotting ticks easier.
. You can substantially increase your level of protection against both ticks and mosquitoes by applying a DEET based or other repellent to your skin, and by pre-treating your clothing with .5% permethrin spray. A single application of permethrin to your clothing can provide up to six weeks of protection, even after repeated washings.
Daily tick check.
The single most important step in reducing your chances of contracting tick-borne illnesses is the daily tick check. Be sure to check yourself, your children and pets after spending time outdoors in tick endemic areas. Use the sensitivity of your fingertips to feel for small bumps, starting with a thorough inspection of the:
Orthomolecular Nutrition & Wellness Center uses multiple testing methods but mainly the Borrelia culture test from Advanced Laboratory Services for the following reasons:
CULTURE vs. SEROLOGY
- Culture is more sensitive (94% vs. <50% for serologies)
- Culture is 100% specific, vs. 70%-80% for serologies
- Culture indicates active infection; serologies only show past exposure
WHEN TO DO A CULTURE
- Initial diagnosis
- Seronegative suspected Lyme
- Patient with borderline/in determinate or conflicting Lyme serologies
- Co-infected patients, to confirm the presence of Borrelia
- Post treatment, symptomatic patients
- Newborns (collect cord blood)
- Recipients of the Lyme vaccine
- Immunosuppressed patient (more likely to have a false negative serology)
- Concurrent viral illness (which may give a false positive Lyme serology)
- New tick bite in a patient with a prior history of Lyme
Check the link below for the latest research paper on the "Improved Culture Conditions for the growth and detection of Borrelia from Human Serum"
Do antibiotics always work to treat Lyme disease?
While antibiotics and other prescription meds are certainly helpful in treating the disease and the all-to-common tick-borne co-infections that often hitchhike into your body through a tick bite. Antibiotics alone may not suffice because Lyme disease is caused by an intracellular spirochete bacterium called Borrelia burgdorferi. "Intracellular means that the spirochete gets into the cell and therefore is not always available to the antibiotics," explains Isaac Eliaz, MD, coauthor of the journal report and founder of Amitabha Medical Clinic and Healing Center in Sebastopol, California. "The cell membrane inadvertently protects the bacteria and shields it from the antibiotics. The bacteria can also hide dormant in the nervous system, among other places such as in biofilms, where antibiotic drugs can't reach them."
What are BioFilms?
A biofilm is a multicellular colony of multiple species of microorganisms and extracellular materials (materials outside of cells) that stick to one another or a surface. In some camps, biofilms are referred to as "slime," although when viewed with a microscope, fibers are present. The growth and proliferation of disease causing pathogens depends on biofilm. Although not all bacteria form biofilm, Lyme spirochetes are shown to aggregate within them.
How do BioFilms affect Lyme Disease?
Lyme spirochetes are found to aggregate (gather) in biofilms. Until 2009, protocols focused on eradicating individual pathogens, with little attention paid to biofilms. Especially in chronic infections, newer protocols address biofilm as a colony of different organisms with a defensive barrier. This is one of the main reasons high dose antibiotics are not usually successful in treating chronic lyme. The practitioner has not addressed the removal of the biofilm before treatment.
Within the protective barrier of biofilms, pathogens aggregate and multiply, greatly increasing virulence. Enzymes and other agents are recommended in lyme disease protocols to degrade and destabilize the pathogenic biofilm "slime" organism/layer.
Orthomolecular Nutrition & Wellness uses multiple modalities to treat chronic lyme that may include IV Nutrition, UVBI and many others. But the most important of them all is bringing down the Lymes defense through a Biofilm removal protocol.
To find out more about our treatment protocols please contact the clinic and set up an appointment at (727)-518-9808.
What Is Bioidentical Hormone Therapy?
Hormone levels decline as we age; bioidentical hormone therapy replenishes the hormones that your body needs to function. Orthomolecular Nutrition and Wellness bioidentical hormone experts use natural or bioidentical hormones versus bio-similar or synthetic hormones. Bioidentical hormones are molecule-by-molecule, exactly the same as the hormones (estrogen, testosterone, progesterone, cortisol, dhea, estradiol and estriol) present in the human body. Our functional medicine practitioners will assess your individual needs and work to restore these hormones and customize a medical plan specifically for you. Health problems associated with hormone imbalances and may include some of the following.
- Fat Weight Gain
- Loss of Muscle Mass and Strength
- Loss of Bone Mass and Strength
- Joint Pains
- Decreased Libido
- Loss of Erectile Ability
- Mental Confusion
- Sleep Loss
- Migraine/Severe Headache
To take our hormone profile click on the appropriate Male or Female tab below and provide us with the valuable information we need to get you started on a new rejuvenated life!